As noted in my overview of Linux accessibility, Debian has, for quite some time now, been a very good choice for a blind user looking to get into Linux. It offers a speech and braille enabled installer and automatically sets up any necessary accessibility settings if they’re available,

no matter which desktop environment you choose.

This video explores the accessibility options provided by both Debian itself, as well as the XFCE desktop, and mentions a few important things to consider if you want to go with this combination.